It’s not often that head coach Dabo Swinney and his Clemson Tigers play on a Friday night. Clemson has only played three games in his tenure on that day of the

Clemson QB Cade Klubnik has been battling an ankle injury and quad contusion. Tigers coach Dabo Swinney gave an update on his health on Nov. 11.

Clemson is coming off a much-needed 24-10 win over Florida State that ended a long home drought against Power 4 opponents. Louisville, on the other hand, is looking to bounce back from a stunning overtime loss to Cal, a game the Cardinals were heavily favored to win.

This article was originally published on www.si.com/college/louisville as Depth Charts: Louisville vs. Clemson. LOUISVILLE, Ky. - The Louisville football program has a short turnaround in store this week, welcoming Clemson to L&N Stadium for yet another primetime matchup. Kickoff is set for Friday, Nov. 14 at 7:30 p.m. EST.

Clemson coach Dabo Swinney gave a huge injury update on quarterback Cade Klubnik ahead of their ACC matchup at Louisville.

Find single game tickets to the Louisville Cardinals vs. Clemson Tigers college football Week 12 matchup on Friday, November 14, 2025 at L&N Federal

Nov 2, 2024; Clemson, South Carolina, USA; Louisville Cardinals running back Isaac Brown (25) runs the ball against Clemson Tigers cornerback Jeadyn Lukus (10) during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-Imagn Images / Ken Ruinard / USA TODAY NETWORK via Imagn Images