San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN ...

For Lions defensive coordinator Aaron Glenn's money, 49ers star George Kittle is the best tight end in football.

The Detroit Lions and the San Francisco 49ers will go head to head for Monday Night Football this week, but tight end George ...

San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

San Francisco 49ers top scorers look to capitalize on opportunities early against Detroit Lions stout defense.

The 49ers are eliminated from the playoffs. But don't tell Kittle or Samuel that, with both studs having two of their best ...

The Detroit Lions visit the San Francisco 49ers on Monday at 8:15 p.m. ET, in a matchup featuring a pair of the best ...

David Montgomery (knee) is the only player missing from the active roster. The starting running back remains in limbo, with ...

Best streaming services for Lions vs. 49ers. Detroit Lions vs. San Francisco 49ers will be aired locally in the Bay Area. It ...

It's a recipe that's as versatile as it is simple. Pair it with tortilla chips, quesadillas, tacos — whatever you want on ...

The Detroit Lions and San Francisco 49ers met 11 months ago at Levi's Stadium with a trip to the Super Bowl on the line. San Francisco used a furious second half comeback to steal the NFC Championship ...

The playoff-eliminated San Francisco 49ers are set to host the Detroit Lions on Monday night in a rematch of last season's ...