Levodopa is the most effective treatment to ... selegiline and rasagiline, decrease dopamine metabolism at the dopaminergic synapse. They provide mild symptomatic benefit and there is also ...

COMT inhibitors exert their therapeutic effects by inhibiting the metabolism of levodopa to 3-O-methyl-dopa. When administered in concert with levodopa and a dopa decarboxylase inhibitor such as ...