Long-term bisphosphonate therapy can change bones at the microscopic level to make them more susceptible to the rare catastrophic transverse breaks known as atypical femoral fractures (AFFs), ...

CHICAGO -- While the widely reported adverse effects of long-term bisphosphonate treatment in osteoporosis patients are certainly real, undertreatment of fracture risk now appears to be gaining, a ...

This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major ...

Osteoporosis, a disease characterized by reduced bone mass and increased skeletal fragility, affects 10 million Americans; another 34 million are at risk for it. Bisphosphonates are widely prescribed ...

Background: Both raloxifene and bisphosphonates are indicated for the prevention and treatment of postmenopausal osteoporosis, however these medications have different efficacy and safety profiles. It ...

To present the clinical features and management outcomes in a large longitudinal series of patients with craniofacial fibrous dysplasia (CFD). A total of 42 patients with CFD were identified. The mean ...

Question: I have been diagnosed with fibrous dysplasia in my left fibula. I have been to two surgeons who have both recommended surgery to remove the abnormal bone and replace it with bone grafts. I ...

An 11-year-old Maine girl is recovering from her fourth surgery to treat fibrous dysplasia, a condition in which a defective gene causes fibrous bone tissue to grow in place of one or more normal ...

SAN FRANCISCO — The presence of fibrous dysplasia alone, without associated visual loss, is not sufficient to warrant prophylactic decompression of the optic nerve, surgeons here advise. Janice S. Lee ...