Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory ...

Cell division drives somatic evolution but is challenging to quantify. We developed a framework to count cell divisions with DNA replication-related mutations in polyguanine homopolymers. Analyzing ...

Loss of GATA6-a transcription factor that controls which genes are turned on or off-can reprogram colorectal cancer cells ...

Loss of GATA6—a transcription factor that controls which genes are turned on or off—can reprogram colorectal cancer cells ...

Breast cancer is one of the most common malignancies among women. Triple-negative breast cancer (TNBC) is a distinct subtype of breast cancer characterized by the absence of estrogen receptor (ER), ...

Researchers found that loss of GATA6 reprograms colorectal cancer cells into flexible, fetal-like states that can spread to ...

Tumor cells can lapse into a sleep-like state and thereby evade the destructive effect of cancer drugs. In some types of the ...

Research from Umeå University paves the way for a quantitative data analysis method to study the cell division process in individual cells. The improved resolution will promote advanced cell analysis ...

For successful cell division, chromosomal DNA needs to be packed into compact rod-shaped structures. Defects in this process can lead to cell death or diseases like cancer. A new study has shown how ...

Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...