Cyclone is a portable gene-switch system that uses acyclovir to reversibly control gene expression with minimal toxicity.

Investigators at Weill Cornell Medicine have developed a versatile and non-toxic technology for controlling the activity of ...

A figure from the paper illustates a key finding of "compromised compartmentalization": chromatin that was locking genes down in health became more open in Alzheimer's, while chromatin that was open ...

The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able ...

Weill Cornell Medicine scientists created Cyclone, a simple tool that uses the antiviral drug acyclovir to safely switch ...

Our experiences leave traces in the brain, stored in small groups of cells called engrams. Engrams are thought to hold the ...

In the new paper, the researchers devised a way to control gene expression levels by changing the distance between the synthetic gene and its promoter. They found that when there was a longer DNA ...