The formation of fingers and toes in mice depends on multiple, interlocking signaling pathways, researchers in this week's Science report. These linked pathways protect the process of digit formation ...

Split hand-split foot malformation (SHFM; OMIM 225300) or ectrodactyly is a congenital defect of digit formation characterized by aplasia of the central digits with fusion of the remaining digits.

The reason we humans have fingers today may all be thanks to a fish's clacker. New research into the origins of digit formation shows that the DNA switch controlling finger and toe development got its ...

Dev. Cell https://doi.org/10.1016/j.devcel.2022.03.004 (2022) During embryogenesis, digit formation may be regulated by either actively signalling organizing centres ...

How Fish Anatomy 380 Million Years Ago Gave Us Fingers (Image: Canva) Our fingers may owe their existence to a long-forgotten feature of ancient fish. New research suggests that the genetic switch ...