Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open ...

Berkeley Lab and UC Berkeley physicists' new technique offers detailed images of the small molecules and cell structures that ...

Biohub and UC Berkeley show that the laser phase plate, a revolutionary device with a laser 100 million times brighter than the Sun, dramatically improves images obtained through cryo-electron ...

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th-century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells ...

Protein crystallization inside living cells occurs naturally and serves roles such as storage, protection, solid-state catalysis, and, in some cases, arises from progression of disease or infection 1.

A new microscope method reveals details that were difficult to see before, helping researchers study proteins, cells, and ...