Transcription Factors (TFs) are pivotal regulators of gene expression and have been implicated in a variety of diseases, including cancer, neurological disorders, autoimmune conditions, and metabolic ...

Transcription factors are the most powerful genes in our body. They are master regulators and have been implicated in our biggest diseases, even aging itself. Yet, many in the pharmaceutical industry ...

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature ...

The immune system regulates homeostasis by attacking foreign bacteria, viruses, and other infections. Different immune cells are generated for specific functions to fight off disease and to maintain ...

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate ...

Some things just go together like “rock and roll” and “fish and chips” or, in molecular biology, “transcription factors” and the “nearby genes they regulate.” The standard, simplified story goes like ...

For the first time, researchers at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a genome-scale way to map the regulatory role of transcription factors ...

The morning glory transcription factor EPH1 binds in the vicinity of genes associated with programmed cell death after a certain time after flowering and activates the expression of these genes. The ...

For the first time, researchers have developed a genome-scale way to map the regulatory role of transcription factors, proteins that play a key role in gene expression and determining a plant's ...