UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors ...

Chemerin is a key adipokine that regulates lipid metabolism and insulin sensitivity, and thus is involved in many metabolic ...

A number of membrane proteins that are present on the cell membrane control external and internal material transportation, cell protection and signal transmission. The diversity of functions of ...

The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...

G protein-coupled receptors (GPCRs) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases. Upon binding to extracellular agonists, ...

GPCRs possess a heptahelical structure and support normal transmembrane cell signaling processes for growth and cellular development. They are mainly found in eukaryotes but have also been observed in ...

G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets. However, a detailed mechanistic understanding of their complex ...

The objective of the study was to demonstrate and characterize IgG Fc receptors of Mycoplasma synoviae. Two IgG Fc receptors were recognized with molecular weights (MW) of 80,000 and 90,000 and ...

Scientists have visualized for the first time how opioids such as loperamide and the antidote naloxone engage a key brain receptor, offering insight that could lead to better pain treatments.