The NMDA receptor, a brain protein crucial for learning and memory, can function as a "frequency discriminator," translating stimulation frequency into current amplitude and possibly deciding whether ...

The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

Elaine C. Budreck, Oh-Bin Kwon, Jung Hoon Jung, Stephane Baudouin, Albert Thommen, Hye-Sun Kim, Yugo Fukazawa, Harumi Harada, Katsuhiko Tabuchi, Ryuichi Shigemoto, Peter Scheiffele, Joung-Hun Kim ...

Two new publications add to growing evidence that toxic Aβ oligomers play havoc with neurons by interfering with N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) and Ca2+ flow, but they ...

Members of the N-methyl-D-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in ...

A scientific study describes that GluN3A subunits of NMDA receptors that interact with glutamate —the main exciting neurotransmitter in the nervous system— are therapeutic targets against Huntington's ...

Researchers identify neurotoxic protein complex and a pharmacological inhibitor that opens new perspectives for developing ...

The N-methyl-D-aspartate receptors (NMDAR) are cation channels in the brain that play important roles in the transmission of nerve impulses and neuronal plasticity. These ligand-gated channels have ...

The FDA approved combination dextromethorphan and bupropion extended-release tablets (Auvelity) for adults with major depressive disorder (MDD), Axsome Therapeutics announced on Friday.