HCN channels, or hyperpolarisation‐activated cyclic nucleotide‐gated channels, are integral membrane proteins that underpin the rhythmic activity of neurons and cardiac pacemakers. These channels ...

Binding of 3',5'-cyclic adenosine monophosphate (cAMP) to hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels regulates their gating. cAMP binds to a conserved intracellular cyclic ...

Electrical signals regulate the rhythmic contractions of the heart muscle and thus control heartbeat. If the signals go awry, the consequences can be lethal. Researchers have now delineated how ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.