'Inside-out' signalling causes integrins such as lymphocyte function-associated antigen 1 (LFA1; also known as αLβ2 integrin) to switch from a bent form to an extended form that more easily binds ...

Pfizer's integrin αvβ6-targeting Antibody-Drug Conjugate (ADC) candidate, Sigvotatug Vedotin (PF-08046047, also known as SGN-B6A), has progressed to Phase III clinical trials for PD-L1 high-expressing ...

High levels of IB6 are often found in NSCLC, making it a good target for treatment. A preclinical study found that in lung cancer, IB6 was correlated with interleukin-8 levels and promoted cancer cell ...

Integrins are heterodimeric, transmembrane receptors that function in cell adhesion and signalling. They are central to many disease states, including cancer, thrombosis, multiple sclerosis and ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...