The analysis of the human brain is a central goal of neuroscience. However, for methodological reasons, research has largely focused on model organisms, in particular the mouse. Now, neuroscientists ...

Exactly 200 years after the discovery of the trace element selenium, researchers have shown for the first time why this chemical element is indispensable for mammalian life. As integral part of the ...

Researchers have developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a ...

This is a preview. Log in through your library . Abstract Single interneurons influence thousands of postsynaptic principal cells, and the control of interneuronal excitability is an important ...

The expression "once bitten, twice shy" is an illustration of how a bad experience can induce fear and caution. How to effectively reduce the memory of aversive events is a fundamental question in ...

Researchers at the University of Virginia School of Medicine have uncovered how problems in cortical microcircuits in the brain can trigger epileptic seizures. The researchers say that targeting the ...

An LSU Health New Orleans research study led by Siqiong June Liu, PhD, Professor of Cell Biology and Anatomy, has found that cerebellar inhibitory interneurons are essential for fear memory, a type of ...

This is a preview. Log in through your library . Abstract The tight balance between synaptic excitation and inhibition (E/I) within neocortical circuits in the mammalian brain is important for complex ...

One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited, firing overtime and ultimately being poisoned by their own activity (Rao ...