Several components of the canonical pathway of response to lipopolysaccharide (LPS) are required for the EGF-dependent activation of NFκB. Conversely, the ability of Toll-like Receptor 4 (TLR4) to ...
Gram-negative bacteria including Escherichia coli, Citrobacter rodentium, Salmonella typhimurium, and Shigella flexneri are sensed in an ill-defined manner by an intracellular inflammasome complex ...
A phase II study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair–proficient (MMR-p) advanced colorectal cancer. This is an ASCO Meeting Abstract from the ...
Maternal health and other events occurring during pregnancy determine the health outcomes in offspring. Pre-natal infections are a major risk factor contributing to compromised intestinal barrier ...
Tsukuba, Japan - The inability to adequately respond to infection can cause a whole-body state of inflammation known as sepsis. This can eventually lead to systemic inflammatory response syndrome ...
In vitro and preclinical studies have demonstrated that lipoproteins, notably high-density lipoprotein, can bind and neutralize endotoxin. Clinical studies revealed poor outcomes in critically ill ...
Bacteria in the gut microbiome drive the formation of cerebral cavernous malformations (CCMs), clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures. The ...
Scientists reveal that the structure of gut bacteria-derived LPS determines whether cancer immunotherapy succeeds or fails—unlocking a new path to personalized treatments. Analysis: Gut ...
Researchers report the first structural confirmation that endogenous -- or self-made -- molecules can set off innate immunity in mammals via a pair of immune cell proteins called the TLR4-MD-2 ...
Results that may be inaccessible to you are currently showing.
Hide inaccessible results
Feedback