They were randomized to flexible doses of Stalevo or levodopa/carbidopa IR administered four-times daily on a q3.5 h schedule with a target dose of approximately 400 mg levodopa per day.

Carbidopa 50mg, levodopa 200mg, entacapone 200mg; tabs. Swallow whole; max one tablet per dosing interval. Previously on carbidopa/levodopa and entacapone: substitute on a mg/mg basis. Stalevo 50 ...

They help manage "wearing off" episodes at the end of levodopa doses, which occur when Parkinson's symptoms, such as muscle stiffness and loss of muscle control, return between doses of medication.

5 dosage is about 8 hours ... "It is noteworthy that the smooth Levodopa blood profile of LXM.5 is reminiscent of that achieved with pump systems, which place a significant burden on patients ...

Clinicians must remember that using two tablets of Stalevo at once not only increases the levodopa but doubles the entacapone dose to 400 mg so that it is recommended instead to use a single ...