Conner, who has a career-high 1,500 scrimmage yards this season, suffered a right knee injury in the second half of the Cardinals’ Week 16 loss to the Panthers, eliminating them from playoff contention. He was not ruled out but spent the remainder of the game on the sidelines in a jacket and did not return.

The Arizona Cardinals are heavily reliant on their run game, which ranks fifth in the NFL in rushing yards and second in yards per carry. That's what makes James Conner's knee injury something to monitor leading up to Saturday night's game at SoFi Stadium.