Researchers at UC Santa Barbara identified a pain pathway in fruit flies that reduces the sensation of pain from heat. The researchers discovered that just a single neuron on each side of the animal’s ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 1 (January 7, 2020), pp. 698-707 (10 pages) Group III/IV muscle afferents transduce nociceptive signals ...

Pain is good. It's the body's way to keep an animal from harming itself or repeating a dangerous mistake. But sometimes the debilitating sensation can get in the way. So evolution has devised ways to ...

Our ears have built-in secret "bodyguards" that protect them from extremely loud, potentially damaging noise, researchers say. A newly detected connection between the inner ear and the brain can warn ...

The neural mechanisms of many symptoms associated with migraine have yet to be elucidated. New research suggests that a non-image-forming retinal pathway and signals from the dura mater contribute to ...

Inner hair cells (IHCs) and outer hair cells (OHCs) in the cochlear organ of Corti (OOC) are destroyed by high-amplitude, persistent sound; however, because the OOC is not innervated by somatosensory ...

People sometimes mistakenly think of general anesthesia as just a really deep sleep but in fact, anesthesia is really four brain states -- unconsciousness, amnesia, immobility and suppression of the ...

In nociception, a range of G-Protein-Coupled Receptors (GPCRs) plays extremely important roles. By modulating the function of a wide variety of ion channels, GPCRs also signal molecules in the case of ...

Please provide your email address to receive an email when new articles are posted on . Nociception is the pathophysiology of actual or potential tissue damage. Pain is the unpleasant thoughts, ...

Osaka, Japan - Candida albicans infection (candidiasis) can cause skin, genital, or oral pain. Many studies have attempted to understand the source of pain in candidiasis; none have provided a clear ...

Osaka University study shows that the Dectin-1 to TRP channel pathway is a novel signaling mechanism in the onset of pain, and that inhibition of the VNUT ATP transporter blocks candidiasis-mediated ...