Nociceptors can be activated and eventually sensitized by several pro-inflammatory mediators, including cytokines and chemokines. These mediators cause profound changes in sensory neurons, including ...

Morphine-induced analgesia and antinociceptive tolerance are known to be modulated by interaction between δ-opioid receptors (DORs) and μ-opioid receptors (MORs) in the pain pathway. However, evidence ...

May 1, 2003 -- Central nociceptive hyperexcitability may be important in fibromyalgia (FM), according to the results of a study published in the May issue of Arthritis & Rheumatism. The nociceptive ...

The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself ...

Nociceptive pain in shoulders, arms and hands can be triggered by repetitive musculoskeletal and/or joint movement injury that can occur with repeated transfers, use of a manual wheelchair and other ...

New research has uncovered that the true cause of fibromyalgia is an excess number of specific nerves found near a specific kind of blood vessel in the hands and feet, ending the controversy over the ...

A UAB study in Alzheimer’s disease in mice demonstrates that pain caused by a harmful external stimulus is preserved in all phases of the disease, even in the most advanced phases, and that there are ...

Holding your hand over a hot burner triggers an immediate threat response and prompts action to address that threat. The sequence is part of the protective pain response known as the nociceptive pain ...

Announcing a new article publication for BIO Integration journal. Combretum leprosum Mart. serves as a medicinal plant in traditional Brazilian medicine. The beneficial effects of C. leprosum Mart.