Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Scientists have visualized for the first time how opioids such as loperamide and the antidote naloxone engage a key brain receptor, offering insight that could lead to better pain treatments.

We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic mucosa from patients and mice with colitis released ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

July 11 (UPI) --While scientists have long noted a complex connection between a person's addiction to opiates, or "opioid use disorder," and chronic pain, the brain mechanisms linking the two have ...

Synthetic opioids like fentanyl are now the main drivers of fatal overdoses in the US, yet current treatment of the addiction is haphazard and often prohibitive. But new research has uncovered a ...

Researchers used emergent MRI technology to understand the impact of prenatal opioid exposure on early brain development and the neural mechanism behind current medications. “Choose life. Choose a job ...

Listening to a favorite song can trigger a profound emotional response that rivals the feelings produced by biological ...

Scientists have discovered that the body can naturally dull pain through its own localized “benzodiazepine-like” peptides. A groundbreaking study led by a University of Leeds scientist has unveiled ...

Chronic pain is a daily reality for millions of Americans, interfering with their everyday activities and quality of life. An ...