Peripheral sensitization refers to the lowering of the threshold of excitability of sensory neurons, which leads to an amplified reaction to a specific external stimulus. Sensitization can be mediated ...

Neuropathic pain arises directly from a lesion or disease affecting the somatosensory system. Our current knowledge on the mechanisms of neuropathic pain comes largely from animal models of peripheral ...

Despite extensive research, the pathogenesis of pain in fibromyalgia syndrome is incompletely understood. Fibromyalgia pain is consistently felt in deep tissues including ligaments, joints and muscles ...

There are the unfortunate patients who develop pain hypersensitivity. These patients have a pain threshold that is lower than normal, and the duration of the pain response can become long-lived. There ...

Injury to tissue and nerves initiates an inflammatory response that is intended to contain pathogens, clear damaged tissues and promote repair. As one of the five cardinal signs of inflammation, pain ...

Fig 2. Basic mechanisms of pain processes at peripheral, spinal, and supraspinal sites and influences of various peripheral mechanisms, including tumor cell– and immune cell–mediated release of ...

Neuropathic pain poses a huge burden on public health and significantly affects quality of life. Yet the current therapies are often inadequate. Therefore, there is an urgent need for a better ...

Please provide your email address to receive an email when new articles are posted on . WAIKOLOA, Hawaii — Properly distinguishing the symptoms of neuropathic pain from dry eye disease can help reduce ...

Neuropathic pain owing to lesions or disease of the nervous system remains a major neurological challenge. We now have to change the way we classify, diagnose and treat neuropathic pain from an ...