Nature

Evaluation of alternative methods for estimating the precision of REML-based estimates of variance components and heritability

Residual Maximum Likelihood (REML) analysis is the most widely used method to estimate variance components and heritability. This method is based on large sample theory under the assumption that the ...
JD Supra

There Is No One-Size-Fits-All Sample Size Appropriate for TAR Validation (Part I)

Acknowledgments: I am grateful to Mary Mack, CEDS, CISSP, for her valuable feedback on an early draft of this piece. At some point eDiscovery practitioners seem to have tacitly agreed that sample ...
ascopubs.org

Bayesian Sample Size Planning Tool for Phase I Dose-Finding Trials

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE BayeSize applies the concept of effect size ...
Nature

Precision estimates of longitudinal brain aging capture unexpected individual differences in one year

Longitudinal studies are required to measure individual differences in human brain aging, but are challenging over short intervals due to measurement error. Using ...