The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

A Jacksonville mom reached out after seeing my story on Akshay Bhatia. Her 4-year-old daughter Harlow has the same rare disease — Pyruvate Dehydrogenase Complex Deficiency — that Bhatia’s niece Mia ...

CWRU has a decades-long history of research into pyruvate dehydrogenase complex deficiency (PDCD). The pyruvate dehydrogenase complex (PDC) is a multiple enzyme complex in the shape of a pentagonal ...

FDA grants a Type A meeting on December 18th to review new and expanded datasets submitted by Saol to help identify a feasible path forward without the need for an additional clinical trial ROSWELL, ...

The pyruvate dehydrogenase complex consists of many different enzymes (marked in different colours). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...

JACKSONVILLE, Fla. — Harlow Higbee is one-of-a kind. "She's a toddler," said Richard Higbee with a laugh. "She really is a toddler now!" To have a happy, laughing toddler on their hands is a big deal ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published ...

Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...