Chemerin receptor structures disclose new mechanism of lipid metabolism

Chemerin is a key adipokine that regulates lipid metabolism and insulin sensitivity, and thus is involved in many metabolic ...
GEN

Bitter Taste Receptor Engages Compounds Not Just Outside the Cell, but Inside

A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...
JSTOR Daily

Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 49 (December 9, 2014), pp. 17660-17665 (6 pages) A muscle acetylcholine receptor (AChR) has two ...
ascopubs.org

Triple-Negative Receptor Conversion at Metastatic Sites Might Show Better Efficacy in Patients Who Received Sacituzumab Govitecan

Informative Censoring of Progression-Free Survival Data in the TROPiCS-02 Trial: An Unrecognized Bias The following represents disclosure information provided by the author of this manuscript. All ...
JSTOR Daily

Catecholamine-Induced Subsensitivity of Adenylate Cyclase Associated with Loss of β -Adrenergic Receptor Binding Sites

Injection of frogs with β -adrenergic catecholamines for 1-24 hr produces marked subsensitivity of the erythrocyte membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1] to in ...
ascopubs.org

Somatostatin receptor subtypes 1-5 gene expression in multiple sites in the same individual.

Relationship of STAT3-mediated treatment resistance on activated MAPK signaling in pancreatic cancer. Background: Metastatic tumors may be fundamentally different than the primary tumor. This ...
Healthline

What Are Partial Opioid Agonists?

Partial opioid agonists have mixed or limited action when they bind to your opioid receptors. So, doctors often use them to treat opioid use disorder. Protein receptor sites are like keyholes on the ...
Healthline

What Are Opioid Antagonists?

Opioid antagonists help block opioid signaling in the central nervous system, and they include medications such as naloxone and naltrexone. Your central nervous system has many different receptors on ...