Scientists have used gene therapy to regenerate damaged nerve fibers in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness ...

Researchers used gene therapy to regenerate damaged axons in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. In ...

Although mammalian retinal ganglion cells (RGCs) normally cannot regenerate axons nor survive after optic nerve injury, this failure is partially reversed by inducing sterile inflammation in the eye.

Traumatic injury to the brain, spinal cord and optic nerve in the central nervous system (CNS) are the leading cause of disability and the second leading cause of death worldwide. CNS injuries often ...

Traumatic injury to the brain, spinal cord and optic nerve in the central nervous system (CNS) are the leading cause of disability and the second leading cause of death worldwide. CNS injuries often ...

Connecting pieces of information by finding a common thread often takes glaucoma researchers in unexpected directions. Zinc is one such thread that joined together different experts at Boston Children ...

Top row: Cross-sections through the mouse retina show very little free zinc (Zn2+) in normal mice (purple staining, left panel), but high levels after the optic nerve is injured (right panel). Within ...

Regenerative failure in the mammalian optic nerve is generally attributed to axotomy-induced retinal ganglion cell (RGC) death, an insufficient intrinsic regenerative capacity, and an extrinsic ...

Using a massive screen of 400 mouse genes, Yale School of Medicine researchers identified 40 genes that thwart axon regeneration in central nervous system cells. By suppressing those genes, the ...

Brain and spinal-cord injuries typically leave people with permanent impairment because the injured nerve fibers (axons) cannot regrow. A study from Children's Hospital Boston, published in the ...