Reconstructing transcription–translation-coupled DNA replication (TTcDR) in artificial systems is crucial for creating synthetic life; however, existing approaches face limitations mainly due to their ...
The DNA replication process is constantly challenged by exogenous and endogenous sources of genotoxic stress, including DNA lesions, unusual secondary DNA structures, limiting nucleotide levels and ...
Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...