The San Francisco 49ers and star wide receiver Brandon Aiyuk could soon be parting ways. The 49ers placed Aiyuk placed on the physically unable to perform (PUP) list in July while recovering from a season-ending ACL and MCL tear he sustained last season.

The Panthers cannot beat the 49ers. Don’t misconstrue that: The Panthers can win on Monday. They have won six times already this season. But they cannot go toe-to-toe with the 49ers, both teams playing their best, and win. And that makes this game the ultimate litmus test for the Niners.

The San Francisco 49ers have signed kicker Matt Gay to their practice squad to replace Eddy Pineiro, and life's been hectic for Gay recently.

NFL Week 12 odds, picks, predictions, TV channel, streaming information for Monday Night Football between Carolina Panthers and San Francisco 49ers.

Among the decisions the San Francisco 49ers will have to make throughout the offseason, it sounds like trading Mac Jones is a possibility.

The San Francisco 49ers beat the Arizona Cardinals on Sunday at State Farm Stadium. How did it affect their standing heading into Week 12?

Find single game tickets to the San Francisco 49ers vs. Carolina Panthers NFL Week 12 matchup on Monday, November 24, 2025 at Levi's Stadium.

San Francisco 49ers nickel back Upton Stout revealed the toughest wide receiver he has faced during his rookie NFL season.

The San Francisco 49ers have some talent along their defensive line, but they could use more, and that could come early in the 2026 NFL draft.