The 49ers' injury report highlights five who miss practice as the team prepares for its Week 13 matchup against the Browns in Cleveland.

The Cleveland Browns and San Francisco 49ers kicked off their practice week on Wednesday with Thanksgiving just a sleep away. The Browns have been struggling but are hoping QB Shedeur Sanders can help lift the offense and DE Myles Garrett can continue to dominate the competition, setting impressive numbers to start the 2025 NFL season.

Ahead of their game against the Cardinals, the 49ers got a bunch of great health news, though they did add one player to the injury report.

For the three NFC West teams with postseason aspirations, Week 12 proved to be successful. They took care of business without much stress even if some of the scores might not fully suggest it. Before we move on to Week 13,

After Brandon Aiyuk's guarantees for next season have been voided, Jeremy Fowler reports that the saga is "far from over" for the 49ers.

ESPN's Jeremy Fowler provided a reason for the San Francisco 49ers waiving the guarantees on Brandon Aiyuk's contract.

San Francisco 49ers head coach Kyle Shanahan touched on the new report about the bleak future wide receiver Brandon Aiyuk has with the team and he went on to confirm just one part of that report.

Here are the most bet NFL Week 12 Monday Night Football player props bets from BetMGM insights, featuring the Carolina Panthers and San Francisco 49ers.