The Medicines and Healthcare products Regulatory Agency (MHRA) has revised its guidance on sodium valproate use in men, removing a requirement for dual specialist reviews for those already on the ...

Other effective medicines are available for epilepsy and bipolar disorder and valproate should only be used if these don’t work or aren’t suitable for an individual patient. Image Credit: Medicines ...

Preventive antimigraine therapy (PAM) should probably not be considered until the headache frequency exceeds 1 per week. PAM is associated with significant side effects and often with tachyphylaxis ...

Maternal use of valproate during pregnancy has been associated with an increased risk of neurodevelopmental disorders in children. Although most studies of other antiseizure medications have not shown ...