Spinocerebellar ataxia (SCA) is a group of autosomal dominant neurodegenerative disorders clinically showing adult-onset progressive cerebellar ataxia as a cardinal feature. 1 Extracerebellar signs, ...

Spinocerebellar ataxia type 1 (SCA1) is an inherited neurodegenerative disease involving progressive loss of motor and cognitive function resulting from the death of cerebellar neurons. Watase et al.

Study led by Tokyo Medical and Dental University (TMDU) identifies crucial protein that rescues progression of adult spinocerebellar ataxia Tokyo - Spinocerebellar ataxia is a group of ...

Spinocerebellar ataxia is a group of neurodegenerative diseases characterized by progressive incoordination of gait, and is often associated with poor coordination of hands, speech, and eye movements.

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. The trial will evaluate VO659, an antisense ...

Neurodegenerative disorders like Alzheimer’s and Parkinson’s disease result from the loss of specific types of neurons due to abnormal accumulation of mutant proteins. Although specific brain regions ...

SLS-005 contains the active ingredient trehalose, a low molecular weight disaccharide (0.342 kDa) that has been shown to penetrate muscle and cross the blood brain barrier. The Food and Drug ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Back to Healio Riluzole did not improve clinical or ...

A team led by Specially Appointed Associate Professor Tomohiko Ishihara and Professor Osamu Onodera at Niigata University, along with Professor Yoshitaka Nagai at Kindai University, conducted a ...

VO659 is the only clinical-stage candidate targeting the CAG repeat expansion that causes these diseases VO659 was designed to preferentially reduce mutant HTT and spare wild-type HTT Phase 1/2a ...

Disruptive clumps of mutated protein are often blamed for clogging cells and interfering with brain function in patients with the neurodegenerative diseases known as spinocerebellar ataxias. But a new ...

A 23 year-old man presented with slowly progressive gait and limb ataxia, slurred speech and nystagmus over 10 years. Spinocerebellar Ataxia (SCA): (Left) T2-weighted axial MRI; (Middle) T1-weighted ...