WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally ...

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

transcription-blocking ... can activate non-canonical ATM signalling and modulate pre-mRNA splicing The kinase ataxia-telangiectasia mutated (ATM) is a major coordinator of the DNA damage response ...

Humans share a comparable number of protein-coding genes with the simple roundworm Caenorhabditis elegans, yet we are arguably more sophisticated organisms. This difference in complexity is thanks to ...

Spliceosome mutations represent a new generation of acquired genetic alterations that affect both myeloid and lymphoid malignancies. A substantial proportion of patients with myelodysplastic syndromes ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 48 (November 29, 2022), pp. 1-12 (12 pages) Spliceosome activation is the process of creating the ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...

This is a preview. Log in through your library . Abstract Recently, it has been reported that there is a differential subcellular distribution of components of the minor U12-dependent and major ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA—a prerequisite for protein synthesis in the cell. The poorly ...

In a recent paper, a team of researchers explain how the molecular machine known as the spliceosome begins the process of rearranging gene sequences in RNA splicing. Certain diseases such as cystic ...

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a ...