New research from the Snow Center for Immune Health is challenging long-held assumptions about autoimmune disease, revealing ...

Researchers screening roughly 400 transcription factors found that disabling a single protein, NFIL3, allowed CAR T-cells to sustain their tumor-killing activity longer in preclinical models. The ...

A cutting-edge therapy using base-edited immune cells is offering a major breakthrough for patients with one of the toughest forms of blood cancer, T-cell acute lymphoblastic leukaemia. By precisely ...

A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into ...

Signaling is fundamental to how cells sense and respond to their environment—but in immune cells, those signals must be precisely amplified to mount an effective defense against invasive threats. New ...

They had ‘highly sensitized’ immune systems that usually reject donated organs, leaving them with few options for survival.

UCLA researchers gave T cells a protected supply of sugar, allowing them to attack solid tumors more effectively.

Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, supercharges a critical class of immune cells that activate and prepare the body's key cancer-fighters, ...

A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their ...