T lymphocytes are central components of the adaptive immune system, tasked with recognising and responding to a wide array of antigens. Their activation is initiated through the engagement of the T ...

The colorful dots at the center are cytotoxic granules used to destroy infected or cancerous cells. Credit: F. Lemaitre @ ...

Cytotoxic T lymphocytes are the body's specialized "killer" cells, precisely eliminating infected or cancerous cells. Their action relies on a specialized exchange zone called the "immune synapse," ...

Researchers used cryo-expansion microscopy to map the immune synapse in near-native conditions, uncovering structural features that guide T cell targeting, granule release, and tumor cell destruction.

Cryo-expansion microscopy has enabled researchers to visualise the three-dimensional organisation of cytotoxic T lymphocytes destroying cancer cells in their near-native state, revealing nanoscale ...

Immunotherapy with and without radiotherapy following the diagnosis of bone metastasis for stage 4 non-small cell carcinoma. Efficacy and safety of nivolumab plus chemotherapy versus chemotherapy ...

Personalised medicine is already a reality in clinical practice, and CAR-T cell therapy is one of its most promising tools. This innovative approach, which involves genetically modifying the cells of ...