Robertsonian translocation is the most common form of chromosomal translocation in humans. It means that two chromosomes, the structures that make up a person’s DNA, join together in an abnormal way.

These images captured using high-speed atomic force microscopy, represent the snapshots of the protein substrate getting translocated through the SecYEG-SecA complex. The left image indicates the ...

Chromosome translocations are catastrophic genomic events and often play key roles in tumorigenesis. Yet the biogenesis of chromosome translocations is remarkably poorly understood. Recent work has ...

Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific targets ...

Leukemia is an umbrella term for multiple different cancers that form in the blood, one such member of the leukemia family being chronic myelogenous leukemia (CML). CML is caused by a chromosomal ...

STRUCTURAL heterozygosis is the existence in heterozygous state of an interchromosomal or intrachromosomal rearrangement. Fragmentation of two chromosomes and the mutual exchange through reunion of ...

MONGOLISM is usually the result of trisomy of a small acrocentric chromosome in Group 21–22 in the Denver Classification. This is generally referred to as 21-trisomy. These patients have a somatic ...