Rare inherited genetic variants significantly increase familial lung cancer risk, offering new targets for early detection.

CRISPR activation restores FLNC expression and reverses cardiac electrical abnormalities in mice carrying a truncating variant of the gene • The study was led by researchers at the Centro Nacional de ...

A study led by Medical Research Council (MRC) scientists has identified genetic variants in two genes that the investigators say have some of the largest impacts on obesity risk discovered to date.

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking ...

Uncertainty surrounding how truncated titin proteins (TTNtvs) cause dilated cardiomyopathy (DCM) and peripartum cardiomyopathy (PPCM) led to investigations that could better inform therapies for these ...

A new editorial was published in Oncotarget's Volume 15 on July 10, 2024, entitled, "Genotype matters: Personalized screening recommendations for germline CHEK2 variants." Recognized as a ...

A global research team maps how rare and common gene variants jointly drive obesity and metabolic disease, offering fresh clues for equitable, personalized prevention and treatment. Study: Discovery ...

Scientists uncover rare genetic mutations that not only influence the timing of menopause but also heighten cancer risk, providing groundbreaking insights into the genetic factors shaping women’s ...