Pharmacokinetic profiling in mice following a single 5 mg/kg intraperitoneal dose revealed favorable tolerability, metabolic stability in human liver microsomes, and measurable CNS exposure, ...

Cytotoxic T lymphocytes play a crucial role in adaptive immunity, primarily defending against tumors and viruses. These cells develop within the thymus gland and undergo rapid activation upon ...

Chemoradiotherapy in the Management of Locally Advanced Pancreatic Carcinoma: A Qualitative Systematic Review The serine-threonine kinase mammalian target of rapamycin (mTOR) plays a major role in the ...

Aging-US Issue 1 Volume 13 features "PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging" which reported that despite a growing proportion of aged individuals at ...

CD8+ T cells responding to persistent antigenic stimulation, for example during chronic viral infections and cancer, undergo a process named T-cell exhaustion. Exhausted T cells are heterogeneous, ...

Philadelphia, PA, November 19, 2013 – Two years ago, mammalian target of rapamycin or mTOR, a signaling protein, was identified as a key mediator of the antidepressant effects of ketamine, the first ...

A phase II study of oral chlorophyllin in haemorrhagic cystitis secondary to radiation therapy for pelvic malignancies (CLARITY). Multiinstitutional cohort study of patient outcomes in Child-Pugh (CP) ...