The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...

The group of researchers were the first to take snapshots of the moment naloxone reverses an opioid overdose in the brain.

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Researchers from the Turku PET Centre, Finland, have observed that the length of daylight hours impacts opioid receptor levels in brown fat. When daylight hours shorten, the receptor activity levels ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

When the season turns darker and colder, animals’ brown fat starts to grow. The tissue produces heat efficiently and rapidly, and regulates appetite. Brown fat is also present in people. In a new ...

Scientists have visualized for the first time how opioids such as loperamide and the antidote naloxone engage a key brain receptor, offering insight that could lead to better pain treatments.

Listening to a favorite song can trigger a profound emotional response that rivals the feelings produced by biological ...