In its simplest form, the pain circuit in the body can be described as follows: pain stimulates pain receptors, and this stimulus is transferred via specialised nerves to the spinal cord and from ...

Pain is one of our senses – like vision, hearing, or taste. It aids our survival by identifying noxious and harmful stimuli. But unlike the other sensations, it's ethically challenging for us to study ...

Osteoarthritis (OA) is a synovial joint disorder characterised by pain, stiffness, and restricted function. It is often classed as a degenerative disease because the affected joints deteriorate over ...

With just one week to go before the inaugural World Championships in Helsinki, some of the sport's top names are fine-tuning their preparations before jetting off to Finland. As a bridging distance ...

—A better understanding of migraine pathophysiology highlights the functions of calcitonin gene-related peptide (CGRP), which has a critical role in the central and peripheral pathways leading to ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Men and women can’t feel each other’s pain. Literally. We have different biological pathways for chronic pain, which means pain-relieving drugs that work for one sex might fail in the other half of ...

Small-fibre neuropathy (SFN), a disorder of thinly myelinated Aδ-fibres and unmyelinated C-fibres, is clinically characterized by neuropathic pain symptoms and autonomic complaints. Diagnosis of SFN ...