Injuries and veteran leadership clash as key defenders aim to dominate this crucial NFC West showdown. Keep your eyes on ...

It wasn't an easy outing for the San Francisco 49ers in the initial matchup with the Arizona Cardinals. Their rematch with ...

Matt Maiocco highlights five key 49ers to keep an eye on in San Francisco's pivotal Week 11 matchup against the Arizona Cardinals on Sunday.

Quarterback Brock Purdy returns to the starting lineup for the San Francisco 49ers this week after missing six games with a ...

San Francisco 49ers coach Kyle Shanahan is so good at making unremarkable passers play like superstars that it’s becoming ...

Can San Francisco's offense ignite against a vulnerable Cardinals defense? Find out if the 49ers can rebound after last ...

Tom Brady, the former New England quarterback who earned his job and never gave it up after Drew Bledsoe was injured in 2001, said in his role as a Fox Sports analyst, the 49ers should consider ...

San Francisco 49ers running back Christian McCaffery catches a short pass from quarterback Mac Jones for a 19-yard gain.

Seattle Seahawks linebacker Boye Mafe drops Arizona Cardinals quarterback Jacoby Brissett for a 15-yard sack which forces ...

The NFL trade deadline is less than a week away on Tuesday, and the Dallas Cowboys are in position to make an addition before the 3 p.m. CST cutoff.

HOUSTON -- Texans wideout Nico Collins is out of the concussion protocol and set to return against the Denver Broncos in Week 9, he said Thursday. "Blessed to be off the protocol," Collins said.

The Houston Texans were able to beat the San Francisco 49ers in Week 8 despite being without the services of their top receiver, Nico Collins. Collins missed the contest while dealing with the ...