We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus ...

The response of single units in cuneate and gracile nuclei to cutaneous stimulation can be modified by prior stimulation of the motor cortex of the cat. Both excitation and inhibition of these neurons ...

Pain and itch are distinct sensations arousing evasion and compulsive desire for scratching, respectively. It’s unclear whether they could invoke different neural networks in the brain. Here, we use ...