CRISPR-edited tumor-infiltrating lymphocytes are emerging as a promising alternative to CAR T-cell therapy for solid cancers.

An epigenetic mechanism by which tumors manage to hide from the body's immune defenses has just been described by an ...

The colorful dots at the center are cytotoxic granules used to destroy infected or cancerous cells. Credit: F. Lemaitre @ ...

Cytotoxic T lymphocytes are the body's specialized "killer" cells, precisely eliminating infected or cancerous cells. Their action relies on a specialized exchange zone called the "immune synapse," ...

Researchers used cryo-expansion microscopy to map the immune synapse in near-native conditions, uncovering structural ...

The body’s “killer” T cells don’t just attack—they strike with astonishing precision, forming a tiny, highly organized contact zone that lets them destroy dangerous cells without harming their ...

Ipsoprubart, a first-in-class SIRP-targeting therapy, expands into T cell malignancies alongside ongoing pivotal study in secondary hemophagocytic lymphohistiocytosis (sHLH) ...

First-in-human healthy volunteers trial showed SYX-5219 was safe and well toleratedSystemic immunomodulation of type 2 inflammation demonstrated ...

Cryo-expansion microscopy has enabled researchers to visualise the three-dimensional organisation of cytotoxic T lymphocytes destroying cancer cells in their near-native state, revealing nanoscale ...

By deploying a "tag and sort" fix using E3 ligases, scientists successfully cleared the protein buildup and restored T-cell ...