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This important study combines optogenetic manipulations and wide-field imaging to show that the retrosplenial cortex controls behavioral responses to whisker deflection in a context-dependent manner.

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on knowledge of ...

The crystalline form of a drug affects properties such as its solubility, stability, dissolution rate, bioavailability and tabletability, and so understanding the crystalline state is crucial for many ...