Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.

The 49ers and Colts meet for a Monday Night Showdown. Check our NFL odds series for the 49ers-Colts prediction and pick.

Brandon Aiyuk hasn't been a part of the San Francisco 49ers' season, and Kyle Shanahan opened up with his regret amid the ...

The 49ers aren't taking Philip Rivers lightly as the veteran QB returns with the Colts, setting up a high-stakes Monday night ...

San Francisco 49ers coach Kyle Shanahan and running back Christian McCaffrey share their impressions of Indianapolis Colts ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

The path to the 1 seed is possible, and it all begins with the Seahawks and Rams on Thursday Night Football in Week 16. As long as the Seahawks win, the 49ers will control their own destiny when it ...

The San Francisco 49ers might have a new face at linebacker when they visit the Indianapolis Colts in Week 16.

Keep up with the 2025 NFL season on FOX Sports. Prior to the final injury report, which lists players as questionable, doubtful or out, NFL teams use practice designations to update player injury ...

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

McCaffrey ranks third in the league in total scrimmage yards with 1,742. The only players he's behind are Bijan Robinson and ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.