San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Saturday's practice as the team prepares for its Week ...

The 49ers will have running back Isaac Guerendo for Monday Night Football. Guerendo, who missed last week's game with a ...

The San Francisco 49ers are preparing for their Week 17 contest against the Detroit Lions on Monday at Levi's Stadium in ...

Last year, the Lions were 30 minutes from their first Super Bowl apperance. But their 17-point lead evaporated, and their best shot to win a championship ...

The NFL's much-discussed new rule against hip-drop tackles has only produced one penalty flag this season, against Carolina's ...

The San Francisco 49ers are preparing for their Week 17 contest against the Detroit Lions on Monday at Levi's Stadium in ...

Videos are auto-populated by an affiliate. This site has no control over the videos that appear above. San Francisco 49ers ...

The San Francisco 49ers are preparing for their Week 17 contest against the Detroit Lions on Monday at Levi's Stadium in Santa Clara, California. Both ...

The NFL has handed down fines to multiple San Francisco 49ers players for their actions during last weekend's game against the Miami Dolphins, per ...

San Francisco 49ers running back Isaac Guerendo is expected to return from foot and hamstring injuries and play Monday, a ...

The 49ers surprisingly signed veteran center Matt Hennessy off the Atlanta Falcons practice squad to a two-year deal this week. On Friday, offensive ...

The last time Brock Purdy faced the Lions, he beat them in the NFC Championship Game. Now the Lions are coming back to town for revenge. And they're ...