From molecular chaperones to mitochondrial failure, discover how heat reshapes the human transcriptome and drives the biological cascade that links rising temperatures to organ injury and public ...

Most bacteria, including many bacterial pathogens, are surrounded by an outer protective layer of sugar molecules, known as a ...

Extracellular vesicles (EVs) are tiny membrane-bound particles released by cells to transport proteins and other molecules to neighboring cells. Because of this natural delivery ability, EVs have ...

Mitochondria possess their own mRNA translation system, mediated by specialized mitoribosomes. Dysregulation of mitochondrial translation disrupts metabolic homeostasis and is linked to various ...

Siglec-15 has traditionally been understood as an immune checkpoint molecule, primarily located on the cell membrane where it suppresses T-cell function. However, the new research revealed that in SHH ...

Living organisms share an ancestor called the last universal common ancestor, or LUCA. LUCA is estimated to have lived ...

Extracellular vesicles play an important role in cell-to-cell communication by transporting proteins and genetic material. Recently, researchers from Japan discovered that vesicles formed from ...

Therapeutic targeting of the AhR-Siglec-15 axis reveals potent efficacy against SHH medulloblastoma in preclinical models.

Researchers engineered CD4+ chimeric antigen receptor T cells targeting fibrillar amyloid beta and tested them in a mouse ...

Patient-reported outcomes in oncology trials provide a unique, patient-centered perspective of the disease and its treatment beyond overall survival or progression-free survival (PFS). 1 The value of ...

Robert Pattinson recently told IndieWire that filming Denis Villeneuve’s “Dune: Part Three” was hotter than imagined. Similar to the first two movies in the franchise, the latest “Dune” tentpole ...

This fundamental work substantially advances our understanding of how the glycocalyx of cells provide a non-specific barrier for the interaction of viruses with cell-surface receptors. Using both in ...