UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors ...

In 2019, a research group led by Andrés Ozaita, of the Department of Medicine and Life Sciences at Pompeu Fabra University, ...

Oral presentation highlights the first time it's been demonstrated that the DOR is expressed on tumor-associated MDSCs, and that DOR inhibition reprograms multiple mechanisms of MDSC- induced ...

A novel compound strongly improves the efficacy of naloxone, the substance used to reverse overdoses of morphine, fentanyl and other opioid drugs. When administered to mice along with naloxone, it is ...

One of the greatest revolutions in the field of pain medication was the isolation of morphine from the opium poppy in the 19th century. Morphine molecules act as painkillers by attaching themselves to ...

AstraZeneca may have washed its hands of AZD4041 after the opioid use disorder (OUD) prospect demonstrated a potential drug-drug interaction last year, but the pharma’s development partner, Eolas ...

Duke University researchers have devised a promising, potent pain reliever — seemingly without the harmful side effects and addictive highs of opioids. While opioids interact with numerous cellular ...

A new experimental painkiller has shown promise in dulling or eliminating pain without the addictive qualities exhibited by today's most popular opioids. The drug also sidesteps common opioid side ...

Listen to more stories on the Noa app. Mallory Berry was ready to give up. It was 2019, and her addiction—prescription opioids had led her to heroin—had left her bedridden. An infection had eaten ...

Naloxone, the opioid overdose antidote, is a powerful tool in the overdose crisis, allowing friends, loved ones and even bystanders a way to put a fatal overdose in reverse and bring back breathing.

Pain is a universal human experience—essential for survival yet unbearable when it lingers unchecked. From the intensity of post-surgical recovery to the grip of chronic conditions, pain management ...