A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A ...

SUMMIT NDA for bezuclastinib in patients with NonAdvSM submitted in December 2025; APEX NDA submission for bezuclastinib in patients with AdvSM ...

Celldex Therapeutics (NASDAQ:CLDX) executives used a presentation at the Guggenheim Emerging Outlook Biotech Summit 2026 to ...

Male sex and increasing age were consistently associated with higher upper limits of normal serum tryptase concentrations. Serum tryptase, a mast cell-specific protease central to the diagnostic ...

The positive predictive value of gastrointestinal mastocytosis for SM involving the bone marrow was 95%, although sensitivity was only 31%. Gastrointestinal (GI) mastocytosis is predictive of systemic ...

Reference ranges for basal serum tryptase (BST) are an excellent guide to determining whether a patient’s BST value is normal, per their specific tryptase genotype. If the BST is elevated based on the ...

A ratio-based tryptase formula for diagnosing pediatric anaphylaxis in the ED demonstrated higher diagnostic performance than the current consensus formula. “We assessed the diagnostic accuracy of the ...

In a decade-long study, a ratio of serum acute tryptase to serum baseline tryptase above 1.74 showed superior diagnostic performance compared with the current consensus formula, which requires serum ...

Objectives: The cellular basis of painful tendon overuse pathology (tendinosis) is poorly understood. It has been suggested that because of the close anatomical associations between mast cells and ...

The diagnosis of anaphylaxis can be tricky, especially in the absence of known triggers and when other conditions, such as urticaria and asthma, mimic aspects of the reaction. Biomarkers can help to ...

56% mean improvement in Total Symptom Score (TSS) at 24 weeks with 76% of patients achieving at least a 50% reduction in TSS 89% of patients had >50% decrease in serum tryptase by four weeks of ...