Week 16 is where the fantasy football playoffs get real -- and so do the lineup compromises. You’re not benching your ...

The 49ers aren't taking Philip Rivers lightly as the veteran QB returns with the Colts, setting up a high-stakes Monday night ...

San Francisco 49ers TE George Kittle, RB Christian McCaffrey, and DL Keion White discussed the energy inside the locker room, ...

Colts’ Jonathan Taylor; Ricky Pearsall Jr. doesn’t practice but Kyle Shanahan likes his chances to play Monday.

San Francisco 49ers head coach Kyle Shanahan highlighted Indianapolis' run defense, reflected on overcoming injuries, and ...

McCaffrey ranks third in the league in total scrimmage yards with 1,742. The only players he's behind are Bijan Robinson and ...

The San Francisco 49ers have a big Week 16 Monday Night Football clash against the Colts, and here are bold predictions.

Let’s keep the streak going. We have found some success with our NFC West Bold Predictions, but now the heat is on. The Los ...

Lucas Oil Stadium is the location where the Indianapolis Colts (8-6) will meet the San Francisco 49ers (10-4) on Monday.

The Indianapolis Colts can't lose to the San Francisco 49ers, or their playoff hopes will fall into the abyss.

Monday, 8:15 p.m. EST, ESPN. BetMGM NFL odds: 49ers by 6. Against the spread: 49ers 9-5; Colts 8-6. Series record: Colts lead 27-18. Last meeting: Colts ...

Once Bosa was gone, Huff became the 49ers’ top pass rusher (by a wide margin). That meant two things: 1. Opponents started ...