Mar 21, 2024 · The pathophysiology of Hyperosmolar Hyperglycaemic State (HHS) remains incompletely understood. Notably, the measurable insulin secretions surpass those observed in …

Hyperosmolar hyperglycemic state (HHS) is 1 of 2 serious metabolic derangements that occurs in patients with diabetes mellitus (DM) and can be a life-threatening emergency.

Jun 1, 2024 · HHS is often triggered by an acute stressor, which increases levels of cortisol and catecholamines (thereby reducing insulin sensitivity). HHS occurs in patients with enough insulin to …

Hyperosmolar hyperglycemic state is a metabolic complication of diabetes mellitus characterized by severe hyperglycemia, extreme dehydration, hyperosmolar plasma, and altered consciousness. It …

As serum glucose concentration increases, an osmotic gradient develops, shifting water from the intracellular space into the intravascular compartment, causing cellular dehydration. The initial …

As with DKA, the pathophysiology of HHNC varies with the particular patient. Because most patients with HHNC are elderly, decreased renal clearance of glucose produced by the decline of renal …

Note: the presence of some insulin directly inhibits lipolysis; thus, in HHS there is no ketone body production, and no subsequent metabolic acidosis and ketouria (unlike in DKA).

Elevated levels of counterregulatory hormones (glucagon, catecholamines, cortisol, and growth hormone) initiate HHS by stimulating hepatic glucose production through glycogenolysis and …

Nov 3, 2020 · Hyperosmolar hyperglycaemic state (HHS) = Hyperosmotic Hyperglycaemic Syndrome (HHS)

HHS is a complication of diabetes and results from a relative lack of insulin resulting in a triad of severe hyperglycaemia, high serum osmolality and severe dehydration, without marked ketoacidosis