The histamine receptor H 2 belongs to the rhodopsin -like family of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion.

Jul 4, 2025 · Learn how H2 receptors signal the body to produce stomach acid and how this biological pathway is targeted by medications for acid-related conditions.

The two classic histamine receptors, H1 receptor and H2 receptor, are well known as drug targets for allergy and gastric ulcer, respectively. These receptors have lower affinity for histamine than the …

Nov 13, 2025 · The H2 receptor acts as a cellular switch activated by its natural ligand, the neurotransmitter histamine. This activation triggers a cascade of internal events that mediate many …

Dec 8, 2024 · H2 receptor blockers are drugs that are used to treat gastroesophageal reflux disease (GERD) and peptic ulcers. This drug is effective, cheap, and safe for relieving heartburn.

Oct 6, 2025 · Histamine from gastric enterochromaffin‑like cells binds H2 receptors, activates adenylate cyclase, raises intracellular cAMP, and activates PKA to traffic and activate the proton pump, a …

In the respiratory system, H2 receptors act to increase respiratory mucous secretion, smooth muscle relaxation, and airway resistance. H2 receptors are involved in the immune system, and are thought …

H 2 receptor – Found mainly in the stomach lining (parietal cells), H2 receptors regulate gastric acid secretion by stimulating the production of hydrochloric acid.

Nov 21, 2025 · Discover what are H-2 receptors, their key role in regulating gastric acid production, and how H2 blocker medications like Pepcid are used to treat acid-related conditions. Learn about their …

Famotidine is also a selective H 2 antagonist. The only affinity data, in free access journals, found to date relates to the canine H 2 receptor, where famotidine has an IC 50 of 26.3nM [19].